The role of nicotinic acid in pathogenesis and therapy of psoriasis and eczema in patients abusing alcohol  

[Article in Russian]

AL Tischenko, SN Stetsyuk, LD Tishchenko, 
IA Yusupov, FS Khalaf, SM TraoreI

Bulletin of dermatology and venerology  No.2 1998

Abstract

Fifty two patients with psoriasis (n=38) and eczema (n=14) abusing alcohol had significantly reduced blood nicotinic acid levels. Total nicotinic acid in these two groups of patients was only 2703.2 and 38512.8 mg% respectively compared with its normal value 6204.6 mg%. Free and albumin-bound nicotinic acid levels were 1831.6 and 871.0 mg% respectively in psoriatic patients and 30110.7 and 842.1 mg% in patients with eczema compared with 3102.3 and 3104.6 mg% respectively in healthy subjects (n=37). The heavy drinkers had the most severe forms of either disease characterized by extensive rash, strong itching, desquamation, and moist skin.  Therapy of these conditions encountered great difficulty.  Preparations of picamilon and vitamin B6 (pyridoxal phosphate) were used in combination with piracetam (Nootropil) to treat 28 patients with psoriasis, eczema, alcohol abuse.  Based on high therapeutic efficiency of these products bringing blood nicotinic acid levels to normal, they are recommended as choice agents for combined therapy of patients with psoriasis and eczema abusing alcohol. 

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