The effect of nootropic agents on brain mitochondrial
function in the dynamics of craniocerebral trauma
from the age
[Article in Russian]
Novikov VE, Kovaleva LA.
Smolensk Medical Academy, Russia.
A craniocerebral trauma was
modeled in experiments on one-month-old rats.
Oxidative phosphorylation in the brain mitochondria was studied by polarography 1, 4, 7 days and 4 weeks after the trauma. In the posttraumatic period the animals received piracetam (1 g/kg), picamilon (500 mg/kg), pyriditol (100 mg/kg), pantogam (160 mg/kg), ACTH (5-10) (0.1 mg/kg), nooglutyl (25 mg/kg), and GVS (0.5 mg/kg).
It was found that piracetam, picamilon, and nooglutyl have a protective effect on the function of the brain mitochondria during the course of a craniocerebral trauma.