The effect of nootropic agents on brain mitochondrial
function in the dynamics of craniocerebral trauma
from the age aspect

[Article in Russian]

Novikov VE, Kovaleva LA.

Smolensk Medical Academy, Russia.

Abstract

A craniocerebral trauma was modeled in experiments on one-month-old rats.  Oxidative phosphorylation in the brain mitochondria was studied by polarography 1, 4, 7 days and 4 weeks after the trauma. In the posttraumatic period the animals received piracetam (1 g/kg), picamilon (500 mg/kg), pyriditol (100 mg/kg), pantogam (160 mg/kg), ACTH (5-10) (0.1 mg/kg), nooglutyl (25 mg/kg), and GVS (0.5 mg/kg).  It was found that piracetam, picamilon, and nooglutyl have a protective effect on the function of the brain mitochondria during the course of a craniocerebral trauma.

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